Mitochondrial point mutations

Zhejiang University and Chinese Academy of engineering Academician Wang Shiwen Guan Minxin Professor leading the research team, in the study of the pathogenesis of hereditary hypertension, through to 1 typical matrilineal hereditary hypertensive pedigrees tracing study found that mitochondria 4,263 mutation causes high blood pressure.　　Research papers published online April 1, 2011 in the cycle (Circ Res) magazine. Since 2006, team for essential hypertensive pedigrees with maternally inherited features, for epidemiological, clinical medical and molecular genetic and cell biology aspects of in-depth study. In 2007, the research group discovered the 1 Han Chinese family with a typical maternally inherited characteristics. The family comes from hongtong County in Shanxi province. The researchers found that the pedigree with matrilineal mitochondrial 4,263 mutation carried by members. The family of 15 of the 27 members of the matrilineal relatives who suffers from high blood pressure, prevalence as high as 55.6%, is much higher than non-matriarchal members, showing genetic early onset phenomenon.　　This the group with United States Cincinnati and Austria Vienna Medical University collaboration in research found 4,263 mitochondrial point mutations, leading to mitochondrial dysfunction, thereby causing blood pressure. The researchers pointed out that, in patients with hypertension, about 8 million patients with high blood pressure or part under the influence of variation in mitochondria. The study, diagnosis and control on hypertension early stage genes, particularly targeting target treatment will have a profound impact, and for the study of hereditary hypertension has opened up new areas.