Mitochondrial mutation caused

Incidence of hypertension in China more than 160 million people. PLA Wang Shiwen with Zhejiang University, academician Guan Minxin Professor leading the research team, has made new progress in the study on the pathogenesis of hereditary hypertension. Their Shanxi Hongdong County inherited hypertensive pedigrees tracing study found that 4,263 mitochondrial point mutations cause hereditary causes of hypertension is. The study, results published online April 1 in the cycling.hypertension affected by a number of complex common effects of environmental factors and genetic factors, genetic factors account for 30% per cent. In some patients with maternally inherited characteristics of typical and maternally inherited mitochondrial genetic material is unique to genetic patterns. At present, the international genetic study on the relationship between hypertension and mitochondrial small.beginning in 2006, Wang Shiwen and the research team led by Guan Minxin on pedigree with maternally inherited characteristics of primary Hypertension epidemiology, clinical medicine, molecular genetics and cell biology, an in-depth study. In 2007, Wang Shiwen and Guan Minxin research group found a Han Chinese family with a typical maternally inherited characteristics, the family from the hongtong County in Shanxi province. Study finds that the pedigree with matrilineal mitochondrial 4,263 mutation carried by members, 15 people in its 27 matrilineal family members suffering from high blood pressure, matriarchal members of hypertension prevalence as high as 55.6%, is much higher than non-matriarchal members, showing genetic early onset phenomenon. In response, the research group of the United States Cincinnati Children's Hospital and Austria Vienna Medical University collaborative research, found 4,263 mutation of mitochondria, leading to mitochondrial dysfunction, causing blood pressure to rise.researchers point out that, in patients with essential hypertension in China, some 8 million cases of high blood pressure or been part under the influence of variation in mitochondria. The subject study on hypertension early genetic diagnosis and prevention of diseases, in particular targeted target treatment will have a profound impact, and for the study of hereditary hypertension develop a new field.